Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 35 findings · 5 reviews

No studies found 14 · 40%GRADE not reported 0 · 0%Very low 14 · 40%Low 7 · 20%Moderate 0 · 0%High 0 · 0%

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Serum urate normalisation ‐ not reported · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in normalisation of serum uric acid ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in frequency of adverse events ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review