Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

58 questions · 58 findings · 4 reviews · Eyes and Vision

No studies found 23 · 39.7%GRADE not reported 0 · 0%Very low 8 · 13.8%Low 10 · 17.2%Moderate 12 · 20.7%High 5 · 8.6%

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs intravitreal anti‐VEGF

Development of cataract at · adults with centre‐involving diabetic macular oedema

Summary of findings: intravitreal anti‐VEGF plus intravitreal steroid probably leads to higher development of cataract at compared with intravitreal anti‐VEGF (moderate certainty).

1 finding from 1 review

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs macular laser

Development of cataract at · adults with centre‐involving diabetic macular oedema

It is very uncertain whether summary of findings: intravitreal bevacizumab plus intravitreal… changes development of cataract at compared with macular laser (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Pseudophakia vs aphakia

Visual axis opacification · children younger than two years of age with bilateral congenital cataracts

It is very uncertain whether summary of findings table ‐ Pseudophakia changes visual axis opacification compared with aphakia (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Pseudophakia vs aphakia

Glaucoma at 5 years · children younger than two years of age with bilateral congenital cataracts

It is very uncertain whether summary of findings table ‐ Pseudophakia changes glaucoma at 5 years compared with aphakia (very low certainty).

1 finding from 1 review

Summary of findings for NSAIDs vs corticosteroids

Intraocular inflammation measured by proportion of participants with corneal edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs showed no clear difference in intraocular inflammation measured by proportion of participants with… compared with corticosteroids (low certainty).

1 finding from 1 review

Summary of findings for NSAIDs vs corticosteroids

Proportion of participants with cystoid macular edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs may leads to lower proportion of participants with cystoid macular edema 1 week compared with corticosteroids (low certainty).

1 finding from 1 review

Summary of findings: bevacizumab vs ranibizumab

Mean change in visual acuity at 1 year (number of letters) · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in mean change in visual acuity at 1 year (number of letters) compared with ranibizumab (high certainty).

1 finding from 1 review

Summary of findings: bevacizumab vs ranibizumab

Reduction in central retinal thickness at one year · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in reduction in central retinal thickness at 1 year compared with ranibizumab (high certainty).

1 finding from 1 review

Summary of findings: bevacizumab vs ranibizumab

No problems in quality of life domains at one year · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in no problems in quality of life domains at 1 year compared with ranibizumab (moderate certainty).

1 finding from 1 review