Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 36 findings · 7 reviews · Acute Respiratory Infections

No studies found 0 · 0%GRADE not reported 4 · 11.1%Very low 4 · 11.1%Low 3 · 8.3%Moderate 17 · 47.2%High 8 · 22.2%

Corticosteroids vs placebo

Pain resolution · patients with sore throat

Corticosteroids leads to higher complete resolution of pain at 24 hours compared with placebo (high certainty).

2 findings from 1 review

Corticosteroids vs control

Mortality ‐ adults · people with community‐acquired pneumonia

Corticosteroids probably leads to lower mortality ‐ adults compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Mortality ‐ adults ‐ severe CAP · people with community‐acquired pneumonia

Corticosteroids probably leads to lower mortality ‐ adults ‐ severe CAP compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Mortality ‐ adults ‐ non‐severe CAP · people with community‐acquired pneumonia

Corticosteroids showed no clear difference in mortality ‐ adults ‐ non‐severe CAP compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults · people with community‐acquired pneumonia

Corticosteroids probably leads to lower early clinical failure ‐ adults compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults ‐ severe CAP · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ adults ‐ severe CAP compared with control (high certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults ‐ non‐severe CAP · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ adults ‐ non‐severe CAP compared with control (high certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ children · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ children compared with control (high certainty).

1 finding from 1 review

Oral corticosteroids vs placebo or NSAID

Proportion of patients with resolution or improved symptoms at days 3 to 7 · patients with acute sinusitis

Oral corticosteroids probably leads to higher proportion of patients with resolution or improved symptoms at days… compared with placebo or NSAID (moderate certainty).

3 findings from 1 review

Oral corticosteroids vs placebo or NSAID

Proportion of patients with resolution or improved symptoms at days 4 to 14 · patients with acute sinusitis

Oral corticosteroids probably leads to higher proportion of patients with resolution or improved symptoms at days… compared with placebo or NSAID (moderate certainty).

2 findings from 1 review

Oral corticosteroids vs placebo or NSAID

Proportion of patients with resolution or improved symptoms at days 4 to 14 ‐ Co‐treatment with antibiotics · patients with acute sinusitis

Oral corticosteroids may leads to higher proportion of patients with resolution or improved symptoms at days… compared with placebo or NSAID (low certainty).

1 finding from 1 review