Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Patients not using rescue medication at 6 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Use of rescue medication · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) led to higher patients using rescue medication at 8 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg…; GRADE not reported.
1 finding from 1 review
RR 2.02 [1.57, 2.60]
2 studies
GRADE not reported
Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
7 studies
GRADE not reported
Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).
1 finding from 1 review
Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
2 studies
GRADE not reported
Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).
1 finding from 1 review
Patients not using rescue medication at 8 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).
1 finding from 1 review
At least 50% reduction in pain · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported.
3 findings from 1 review
RR 4.87 [2.83, 8.37]
17 studies · 1658 participants
GRADE not reported
RR 3.41 [2.34, 4.97]
13 studies · 1184 participants
GRADE not reported
RR 2.85 [1.89, 4.29]
16 studies · 1498 participants
GRADE not reported
Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 6 hours (using pain relief… compared with placebo; GRADE not reported.
1 finding from 1 review
Major complications at the implant site · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate-delayed implants (placed within 8 weeks after tooth… led to higher major complications at the implant site compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.
1 finding from 1 review
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (horizontal - HDD) compared with bio-Oss + resorbable barrier; GRADE not reported.
1 finding from 1 review
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Non-resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Vertical height of the defect (VDH).
1 study · 25 participants
GRADE not reported
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Non-resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Horizontal depth of the defect (HDD).
1 study · 25 participants
GRADE not reported
Marginal bone level change · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets
Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in perimplant marginal bone level changes compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.
1 finding from 1 review
Prosthesis failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Autogenous bone graft augmentation at the immediate implant site led to lower prosthesis failure compared with no augmentation; GRADE not reported.
1 finding from 1 review
In total two implants were lost in the autogenous bone group, whereas no complications or failures occurred in the non-augmented control group; underpowered, no statistically significant difference (Chen 2005b).
1 study · 26 participants
GRADE not reported
Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences were found between the three procedures (Chen 2005a). Horizontal depth of the defect (HDD).
1 study · 23 participants
GRADE not reported
Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)
Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (vertical - VDH) compared with bio-Oss + resorbable barrier; GRADE not reported.
1 finding from 1 review
All treatments resulted in statistically significant bone gain, however no statistically significant differences in bone gain were found between the two procedures for vertical height of the defect (VDH) (Chen 2007).
1 study · 20 participants
GRADE not reported