What do systematic reviews say?

Simplified vs usual regimens

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1310 participants
  Moderate

Simplified vs usual regimens

Simplified showed no clear difference in exacerbations requiring OCS People with 1 or more compared with usual regimens (low certainty).

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  OR 2.33 [0.17, 32.58]
  1 study · 16 participants
  Low

Simplified vs usual regimens

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 103 participants
  Moderate

Simplified vs usual regimens

Simplified showed no clear difference in unscheduled visits compared with usual regimens (low certainty).

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  OR 1.17 [0.72, 1.9]
  1 study · 1037 participants
  Low

Simplified vs usual regimens

Simplified showed no clear difference in absence from work/school compared with usual regimens (low certainty).

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  OR 0.93 [0.37, 2.3]
  1 study · 1037 participants
  Low

Simplified vs usual regimens

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1037 participants
  Low

Simplified vs usual regimens

Simplified showed no clear difference in all adverse events compared with usual regimens (low certainty).

• Interventions to improve adherence to inhaled steroids for asthma 2017 · Cochrane Headline outcomes only
  OR 0.76 [0.56, 1.04]
  1 study · 1233 participants
  Low

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: any simplified antibiotic regimen showed no clear difference in neonatal mortality compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 0.81 [0.44, 1.5]
  3 studies · 3476 participants
  Moderate

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: any simplified antibiotic regimen showed no clear difference in treatment failure compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 0.86 [0.67, 1.1]
  3 studies · 3476 participants
  Moderate

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.38 [0.79, 2.41]
  3 studies · 3476 participants
  Moderate

Complex vs simplified health education

• Improving vaccination uptake among adolescents 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17411 participants
  Moderate