Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 33 findings · 5 reviews · Wounds · Headline outcomes only

No studies found 14 · 42.4%GRADE not reported 0 · 0%Very low 7 · 21.2%Low 8 · 24.2%Moderate 2 · 6.1%High 2 · 6.1%

Silver vs non‐antibacterial

Wound healing · people with burns

Silver showed no clear difference in wound healing (number of healing events): silver xenograft vs… compared with non‐antibacterial (low certainty).

2 findings from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.13 [0.59, 2.16]
    1 study · 32 participants
    Low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 204 participants
    Moderate

Silver vs non‐antibacterial

Infection · people with burns

The review found no eligible studies for this question.

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Silver vs non‐antibacterial

Adverse events · people with burns

The review found no eligible studies for this question.

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Silver dressing vs exposed wound

SSI Assessment method: CDC definition of SSI · surgical wounds resulting from a range of surgical procedures with some risk of contamination healing by primary intention

It is very uncertain whether silver dressing changes SSI Assessment method: CDC definition of SSI compared with exposed wound (very low certainty).

1 finding from 1 review

Silver‐based antiseptics vs topical antibiotics

Time to complete healing · people with burns

Silver‐based antiseptics showed no clear difference in wound healing: time to complete healing (time‐to‐event data) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    HR 1.25 [0.94, 1.67]
    3 studies · 259 participants
    Low

Silver‐based antiseptics vs topical antibiotics

Wound healing · people with burns

Silver‐based antiseptics showed no clear difference in wound healing (mean time to healing) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 1085 participants
    Low

Silver‐based antiseptics vs topical antibiotics

Number of wounds healed · people with burns

Silver‐based antiseptics showed no clear difference in wound healing (number of healing events) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.17 [1, 1.37]
    5 studies · 408 participants
    Low

Intervention not reported

Silver versus nonadherent · people with venous leg ulcers

The intervention probably leads to higher silver versus nonadherent (moderate certainty).

1 finding from 1 review

Intervention not reported

Silver versus foam · people with venous leg ulcers

The intervention may leads to higher silver versus foam (low certainty).

1 finding from 1 review

Intervention not reported

Silver versus hydrocolloid · people with venous leg ulcers

The intervention may leads to higher silver versus hydrocolloid (low certainty).

1 finding from 1 review

Intervention not reported

Sucralfate versus silver · people with venous leg ulcers

It is very uncertain whether the intervention changes sucralfate versus silver (very low certainty).

1 finding from 1 review