Findings

What do systematic reviews say?

42 questions · 46 findings · 7 reviews

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No studies found 8 · 17.4%GRADE not reported 2 · 4.3%Very low 2 · 4.3%Low 20 · 43.5%Moderate 11 · 23.9%High 3 · 6.5%

Sildenafil vs placebo

PaO2 in mmHg (absolute values) After 24‐25 hours · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 57 participants
Low

Sildenafil vs placebo

Change in oxygenation index ‐ After 24 hours of treatment · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Sildenafil vs placebo

All‐cause mortality · pulmonary hypertension in neonates

Sildenafil may leads to lower all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
RR 0.2 [0.07, 0.56]
3 studies · 77 participants
Low

Sildenafil vs active control

All‐cause mortality · pulmonary hypertension in neonates

It is very uncertain whether sildenafil changes all‐cause mortality compared with active control (very low certainty).

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
RR 0.55 [0.05, 5.75]
1 study · 65 participants
Very low

Sildenafil vs placebo

International Index of Erectile Function questionnaire 31 · patients with erectile dysfunction in patients with multiple sclerosis

1 finding from 1 review

Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 420 participants
GRADE not reported

Sildenafil vs placebo

International Index of Erectile Function ‐ not reported · patients with erectile dysfunction in patients with multiple sclerosis

1 finding from 1 review

Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 420 participants
GRADE not reported

Sildenafil vs placebo

Sexual Encounter Profile questions 2 · patients with erectile dysfunction in patients with multiple sclerosis

Sildenafil showed no clear difference in sexual Encounter Profile questions 2 compared with placebo (low certainty).

1 finding from 1 review

Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis 2012 · Cochrane Headline outcomes only
RR 1.28 [0.92, 1.78]
1 study · 184 participants
Low

Sildenafil vs placebo

Sexual Encounter Profile questions 3 · patients with erectile dysfunction in patients with multiple sclerosis

Sildenafil showed no clear difference in sexual Encounter Profile questions 3 compared with placebo (low certainty).

1 finding from 1 review

Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis 2012 · Cochrane Headline outcomes only
RR 1.38 [1, 1.9]
1 study · 187 participants
Low

Sildenafil vs placebo

Global Assessment Question · patients with erectile dysfunction in patients with multiple sclerosis

Sildenafil probably leads to higher global Assessment Question compared with placebo (moderate certainty).

1 finding from 1 review

Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis 2012 · Cochrane Headline outcomes only
RR 2.72 [1.4, 5.28]
2 studies · 406 participants
Moderate

Sildenafil vs placebo

Effect on later sexual function · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Other untoward side effects of treatment · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Detumescence · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Reduction in frequency of priapism · men and boys with SCD and stuttering priapism

Sildenafil showed no clear difference in reduction in frequency of priapism compared with placebo (low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.58 [0.07, 4.95]
1 study · 13 participants
Low

Sildenafil vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Endpoint International Index of Erectile Function (IIEF) total scores (The IIEF is a self‐report measure with 15 questions examining erectile function, orgasmic function, sexual desire, and intercourse satisfaction. Maximum possible score 75) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ question 3: ability to achieve erection (Maximum score 5) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 231 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ intercourse satisfaction (questions 6, 7, 8) (Maximum score 15) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Moderate

Sildenafil vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Sildenafil probably leads to lower clinical Global Impression ‐Sexual Function not "much/very much… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.44 [0.33, 0.58]
2 studies · 187 participants
Moderate

Sildenafil vs placebo

Dropout · people with antidepressant‐induced sexual dysfunction

Sildenafil showed no clear difference in dropouts (People leaving the trial early) compared with placebo (high certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.68 [0.41, 1.14]
4 studies · 353 participants
High