What do systematic reviews say?

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 184 participants
  Very low

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 91 participants
  Very low

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 256 participants
  Very low

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Very low

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 330 participants
  Very low

Antagonist‐adrenergic combination vs adrenergic agonist

• Opioid antagonists with minimal sedation for opioid withdrawal 2017 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 463 participants
  Very low

Intervention not reported

The intervention may leads to higher number completing detoxification (low certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 1.42 [1.09, 1.84]
  2 studies · 100 participants
  Low

Intervention not reported

The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Clonidine… (moderate certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 4.28 [2.91, 6.3]
  3 studies · 240 participants
  Moderate

Intervention not reported

The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Buprenorphine… (moderate certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 1.29 [1.04, 1.6]
  1 study · 72 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (low certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 2 [0.9, 4.45]
  1 study · 30 participants
  Low

Intervention not reported

The intervention probably leads to higher retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 2.77 [1.37, 5.61]
  3 studies · 240 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 0.82 [0.34, 1.97]
  1 study · 72 participants
  Moderate

Intervention not reported

The intervention probably leads to higher participants experiencing adverse effects (moderate certainty).

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  RR 3.21 [1.13, 9.12]
  2 studies · 572 participants
  Moderate

Intervention not reported

• Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 participants
  GRADE not reported