What do systematic reviews say?

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  12 months
  RR 1.46 [1.11, 1.91]
  1 study · 73 participants
  Very low
• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  48 months
  RR 3.58 [1.86, 6.89]
  1 study · 73 participants
  Very low

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  day 1
  A benefit in pain scores was reported on day 1 in favour of the thymosin alpha 1 group; no difference found on days 2 and 5.
  1 study · 73 participants
  GRADE not reported

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
  Loo 2008 did not report this outcome; following email correspondence, authors reported no adverse effects were seen (uncertain whether formally assessed).
  1 study
  GRADE not reported

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes periodontal healing at 48 months compared with control (saline) (very low certainty).

• Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes

  48 months
  RR 5.60 [2.22, 14.11]
  1 study · 73 participants
  Very low