Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline: Tooth survival
- Population
- People with avulsed and replanted permanent (front) teeth
- Intervention
- Thymosin alpha 1 (10-minute soak prior to replantation)
- Comparison
- Normal saline
- Outcome
- Tooth survival
It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Thymosin alpha 1 (10-minute soak prior to replantation) vs Control (saline) Tooth survival at 12 months · People with avulsed and replanted permanent (front) teeth · 12 months It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty). Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted (2019) · Cochrane All outcomes | RR 1.46 [1.11, 1.91] | 1 study · 73 participants | Very low |
Thymosin alpha 1 (10-minute soak prior to replantation) vs Control (saline) Tooth survival at 48 months · People with avulsed and replanted permanent (front) teeth · 48 months It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 48 months compared with control (saline) (very low certainty). Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted (2019) · Cochrane All outcomes | RR 3.58 [1.86, 6.89] | 1 study · 73 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes | 2018-03 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Thymosin alpha 1 (10-minute soak prior to replantation) vs Saline (control) · Children and young adults with avulsed and replanted permanent teeth · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.