Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 36 findings · 5 reviews · Acute Respiratory Infections

No studies found 12 · 33.3%GRADE not reported 0 · 0%Very low 10 · 27.8%Low 9 · 25%Moderate 4 · 11.1%High 1 · 2.8%

Normal saline plus standard treatment vs usual care

Antibiotic usage Patient‐reported usage · patients with acute upper respiratory tract infections

It is very uncertain whether normal saline plus standard treatment changes antibiotic usage Patient‐reported usage compared with standard treatment alone (very low certainty).

1 finding from 1 review

Magnesium sulphate vs hypertonic saline

Clinical severity score (CSS) (RDAI score; range 0 to 17; higher = poorer outcomes) measured 25 to 48 hoursafter treatment · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate changes clinical severity score (CSS) (RDAI score; range 0 to 17; higher =… compared with hypertonic saline (very low certainty).

1 finding from 1 review