Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Neonatal · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 7 · 87.5%Low 1 · 12.5%Moderate 0 · 0%High 0 · 0%

Saline irrigation with or without prior infiltration of hyaluronidase vs standard wound care

Complete wound healing · neonates requiring management of extravasation injury

1 finding from 1 review

Saline irrigation for the management of skin extravasation injury in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 237 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Necrotising enterocolitis · preterm infants

It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of necrotising enterocolitis (NEC) compared with control (water, saline, or no intervention) (very low certainty).

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
RR 1.42 [0.5, 4.02]
6 studies · 335 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Any late‐onset sepsis ‐ all infants · preterm infants

It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of late‐onset sepsis compared with control (water, saline, or no intervention) (very low certainty).

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.33]
6 studies · 335 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Death of baby (up to discharge) · preterm infants

It is very uncertain whether oropharyngeal colostrum (OPC) changes death before discharge to home compared with control (water, saline, or no intervention) (very low certainty).

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
RR 0.76 [0.34, 1.71]
6 studies · 335 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Time to achieve full enteral feeding (days) · preterm infants

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 335 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Length of hospital stay · preterm infants

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 293 participants
Very low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Pneumonia · preterm infants

Oropharyngeal colostrum (OPC) showed no clear difference in pneumonia compared with control (water, saline, or no intervention) (low certainty).

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
RR 2.08 [0.54, 8.06]
3 studies · 57 participants
Low

Oropharyngeal colostrum (OPC) vs No treatment or saline or water

Reported adverse effects · preterm infants

1 finding from 1 review

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 335 participants
Very low