Findings

What do systematic reviews say?

407 questions · 412 findings · 45 reviews · Headline outcomes only

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No studies found 137 · 33.3%GRADE not reported 8 · 1.9%Very low 129 · 31.3%Low 88 · 21.4%Moderate 47 · 11.4%High 3 · 0.7%

Saline vs no saline treatment

Disease severity score (up to 4 weeks) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Disease severity score (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Individual symptom scores ‐ not measured · allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline vs no saline treatment

Epistaxis · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline vs no saline treatment

Disease‐specific quality of life · allergic rhinitis

2 findings from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low
Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline vs no saline treatment

Other adverse effects: local irritation · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Saline irrigation with or without prior infiltration of hyaluronidase vs standard wound care

Complete wound healing · neonates requiring management of extravasation injury

1 finding from 1 review

Saline irrigation for the management of skin extravasation injury in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 237 participants
Very low

Saline vs carbon dioxide

Tolerability of the procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1705 participants
Low

Saline vs carbon dioxide

Adverse events and complications · women undergoing outpatient hysteroscopy

Saline probably leads to lower adverse events and complications compared with carbon dioxide (moderate certainty).

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
Peto OR 0.53 [0.32, 0.86]
6 studies · 1076 participants
Moderate

Saline vs carbon dioxide

Quality of hysteroscopic view · women undergoing outpatient hysteroscopy

Saline may leads to lower quality of hysteroscopic view compared with carbon dioxide (low certainty).

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
Peto OR 0.51 [0.32, 0.82]
5 studies · 1082 participants
Low

Saline vs carbon dioxide

Duration of the procedureassessed in seconds · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 4 participants
GRADE not reported

Hypertonic saline 7% vs hypertonic saline

FEV1 % predicted: relative change from baseline · children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Hypertonic saline 7% vs hypertonic saline

FEV1 · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

LCI · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

All‐cause mortality · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Measures of sputum clearance · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs hypertonic saline

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Warm saline vs room temperature saline

Tolerability of the procedure · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 241 participants
Low

Warm saline vs room temperature saline

Adverse events and complications · women undergoing outpatient hysteroscopy

1 finding from 1 review

Uterine distension media for outpatient hysteroscopy 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
GRADE not reported