Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 110 findings · 14 reviews · Neuromuscular · Headline outcomes only

No studies found 17 · 15.5%GRADE not reported 21 · 19.1%Very low 47 · 42.7%Low 20 · 18.2%Moderate 5 · 4.5%High 0 · 0%

SPLINT vs No active treatment (control)

Overall improvement (improved/not improved or worsened) ‐ short‐term improvement: < 3 months · carpal tunnel syndrome

SPLINT may leads to higher overall improvement (improved/not improved or worsened) ‐ short‐term… compared with NO ACTIVE TREATMENT (low certainty).

1 finding from 1 review

Botulinum toxin vs placebo

Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

Botulinum toxin injection showed no clear difference in participant‐reported improvement in sialorrhea in the short term… compared with placebo (low certainty).

1 finding from 1 review

Radiotherapy vs botulinum toxin

Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture vs gastrokinetic agents

Proportion of people whose symptoms 'improved' (short term: 4 to 12 weeks) · symptomatic gastroparesis

It is very uncertain whether acupuncture changes proportion of people whose symptoms 'improved' (short term: 4 to 12… compared with gastrokinetic agents (very low certainty).

1 finding from 1 review