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What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 47 findings · 2 reviews

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No studies found 16 · 34%GRADE not reported 2 · 4.3%Very low 4 · 8.5%Low 19 · 40.4%Moderate 5 · 10.6%High 1 · 2.1%

Prostanoids vs placebo

Cardiovascular mortality · people with critical limb ischaemia

Prostanoids showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Adverse events (participants) · people with critical limb ischaemia

It is very uncertain whether prostanoids changes adverse events (participants) compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Rest‐pain relief · people with critical limb ischaemia

It is very uncertain whether prostanoids changes rest‐pain relief compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs naftidrofuryl

Adverse events (participants) · people with critical limb ischaemia

Prostanoids showed no clear difference in adverse events (participants) compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids vs naftidrofuryl

Rest‐pain relief · people with critical limb ischaemia

Prostanoids showed no clear difference in rest‐pain relief compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids vs placebo

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with placebo (high certainty).

1 finding from 1 review

Prostanoids vs placebo

Adverse events (participants) · people with critical limb ischaemia

Prostanoids probably leads to higher adverse events (participants) compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs placebo

Rest‐pain relief · people with critical limb ischaemia

Prostanoids probably leads to higher rest‐pain relief (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs placebo

Ulcer healing · people with critical limb ischaemia

Prostanoids probably leads to higher ulcer healing compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs lumbar sympathectomy

Complete ulcer healing without rest pain or major amputation (per protocol) Clinical assessment · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

Prostanoids may leads to higher complete ulcer healing without rest pain or major amputation (per… compared with lumbar sympathectomy (low certainty).

1 finding from 1 review