Findings

What do systematic reviews say?

22 questions · 22 findings · 3 reviews · Pregnancy and Childbirth

Sort:Best matchNewest Highest certainty Download CSV

No studies found 1 · 4.5%GRADE not reported 2 · 9.1%Very low 1 · 4.5%Low 9 · 40.9%Moderate 8 · 36.4%High 1 · 4.5%

Progesterone vs placebo or no treatment

Miscarriage · women with threatened miscarriage

Progesterone probably leads to lower miscarriage compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Progestogen for treating threatened miscarriage 2018 · Cochrane Headline outcomes only
RR 0.64 [0.47, 0.87]
7 studies · 696 participants
Moderate

Progesterone vs placebo or no treatment

Preterm birth · women with threatened miscarriage

Progesterone showed no clear difference in preterm birth compared with placebo or no treatment (low certainty).

1 finding from 1 review

Progestogen for treating threatened miscarriage 2018 · Cochrane Headline outcomes only
RR 0.86 [0.52, 1.44]
5 studies · 588 participants
Low

Progesterone vs placebo or no treatment

Congential abnormalities · women with threatened miscarriage

It is very uncertain whether progesterone changes congential abnormalities compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Progestogen for treating threatened miscarriage 2018 · Cochrane Headline outcomes only
RR 0.7 [0.1, 4.82]
2 studies · 337 participants
Very low

Vaginal progesterone vs no treatment or placebo

Low birthweight · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in infant birthweight less than 2500 g compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.95 [0.84, 1.07]
3 studies · 2640 participants
Moderate

Vaginal progesterone vs no treatment or placebo

Preterm birth · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 37 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.97 [0.89, 1.06]
6 studies · 1597 participants
Moderate

Vaginal progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.53 [0.79, 2.97]
3 studies · 1345 participants
Low

Vaginal progesterone vs no treatment or placebo

Perinatal mortality · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in perinatal death compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.23 [0.74, 2.06]
3 studies · 2287 participants
Low

Vaginal progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Vaginal progesterone showed no clear difference in preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.9 [0.66, 1.23]
5 studies · 1503 participants
Low

Vaginal progesterone vs no treatment or placebo

Major neurodevelopmental disability at childhood · Women with a multiple pregnancy

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intramuscular (IM) progesterone vs no treatment or placebo

Perinatal mortality · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in perinatal death compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.45 [0.6, 3.51]
6 studies · 3089 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.54 [1.06, 2.26]
2 studies · 399 participants
Low

Intramuscular (IM) progesterone vs no treatment or placebo

Major neurodevelopmental disability at childhood · Women with a multiple pregnancy

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intramuscular (IM) progesterone vs no treatment or placebo

Low birthweight · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in infant birthweight less than 2500 g compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.08]
5 studies · 4071 participants
Moderate

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.08 [0.75, 1.55]
5 studies · 1920 participants
Moderate

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 37 weeks compared with no treatment or placebo (high certainty).

1 finding from 1 review

Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy 2019 · Cochrane Headline outcomes only
RR 1.05 [0.98, 1.13]
5 studies · 2010 participants
High

Cervical pessary vs vaginal progesterone

Maternal infection or inflammation · women with singleton pregnancies at risk of cervical insufficiency

Cervical pessary showed no clear difference in maternal infection or inflammation compared with vaginal progesterone (moderate certainty).

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
RR 0.95 [0.81, 1.12]
2 studies · 265 participants
Moderate

Cervical pessary vs vaginal progesterone

Neonatal/paediatric care unit admission · women with singleton pregnancies at risk of cervical insufficiency

Cervical pessary showed no clear difference in neonatal/paediatric care unit admission compared with vaginal progesterone (low certainty).

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
RR 0.98 [0.49, 1.98]
1 study · 254 participants
Low

Cervical pessary vs vaginal progesterone

Fetal/infant mortality · women with singleton pregnancies at risk of cervical insufficiency

Cervical pessary showed no clear difference in fetal/infant mortality compared with vaginal progesterone (low certainty).

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
RR 1.97 [0.5, 7.7]
2 studies · 265 participants
Low

Cervical pessary vs vaginal progesterone

Harm to offspring from the intervention · women with singleton pregnancies at risk of cervical insufficiency

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
Low

Cervical pessary vs vaginal progesterone

Birthweight (g) · women with singleton pregnancies at risk of cervical insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found