Antidepressants vs antidepressants
Depression remission · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders
No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%
Antidepressants vs antidepressants
Change in depression severity from baseline · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antidepressant plus antipsychotic vs placebo plus antidepressant
Clinical response of depression · adults with psychotic depression
It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).
2 findings from 1 review
- RR 1.42 [1.11, 1.8]4 studies · 245 participantsVery low
- RR 1.7 [1.19, 2.43]3 studies · 157 participantsVery low
Antidepressant plus antipsychotic vs placebo plus antidepressant
Depression remission · adults with psychotic depression
The review found no eligible studies for this question.
2 findings from 1 review
- no estimate extractedStudies not reportedNo studies found
- no estimate extractedStudies not reportedNo studies found
Antidepressant plus antipsychotic vs placebo plus antidepressant
Change in depression severity from baseline · adults with psychotic depression
The review found no eligible studies for this question.
2 findings from 1 review
- no estimate extractedStudies not reportedNo studies found
- no estimate extractedStudies not reportedNo studies found
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression
1 finding from 1 review
- Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes onlyno estimate extracted10 studies · 598 participantsModerate
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression
1 finding from 1 review
- Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 347 participantsLow
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity: continuous phase (> 12 weeks) · patients with major depression
1 finding from 1 review
- Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 50 participantsLow
Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 431 participantsHigh
Augmentation of current antidepressant (SSRI) with busiprone (20 mg/d to 60 mg/d) vs placebo plus antidepressant
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 102 participantsLow
Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 199 participantsModerate
Augmentation of current antidepressant (fluoxetine 20 mg/d) with mianserin (60 mg/d) vs placebo plus antidepressant
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 70 participantsModerate
Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 808 participantsHigh
Augmentation of current antidepressant (various) with quetiapine (150 mg/d to 300 mg/d) vs augmentation of current antidepressant (various) with placebo
Depressive symptoms · treatment‐resistant depression in adults
1 finding from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 977 participantsHigh
Augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with olanzapine (5 mg/d to 20 mg/d) vs augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with placebo
Depressive symptoms · treatment‐resistant depression in adults
2 findings from 1 review
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 20 participantsLow
- Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 20 participantsLow
Antidepressants vs placebo
Clinical response of depression · adults with psychotic depression
It is very uncertain whether antidepressant changes clinical response of depression compared with placebo (very low certainty).
1 finding from 1 review
- RR 8.4 [0.5, 142.27]1 study · 27 participantsVery low
Antidepressants vs antipsychotics
Clinical response of depression · adults with psychotic depression
It is very uncertain whether antidepressant changes clinical response of depression compared with antipsychotic (very low certainty).
1 finding from 1 review
- RR 2.09 [0.64, 6.82]1 study · 36 participantsVery low
Antidepressants vs antipsychotics
Depression remission · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antidepressants vs antipsychotics
Change in depression severity from baseline · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Antidepressants vs placebo
Depression remission · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found