Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Dental caries

No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Salivary S. mutans level · children aged 6 to 12 years

No meta-analysis was conducted; the reduction in salivary Streptococcus mutans count versus fluoride toothpaste was reported as insignificant.

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
4 weeks · clinical setting
no estimate extracted
1 study
GRADE not reported

Increased salivary IgA · children aged 6‐12 years

Postbiotics increase salivary IgA (immune modulation) in human trials (ungraded narrative synthesis).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
Daily for 14 days to 4 weeks · Clinical; salivary/plaque sampling
Postbiotic toothpaste significantly increased salivary IgA versus fluoride toothpaste (Basir 2022); the review also cites Lin 2022 for postbiotic immune modulation/IgA; no pooled estimate.
1 study
GRADE not reported

Increased salivary pH · children aged 6‐12 years

Postbiotic toothpaste raises salivary pH in one pediatric RCT (ungraded).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
4 weeks · Clinical; salivary/plaque sampling
Postbiotic toothpaste significantly increased salivary pH versus fluoride toothpaste in children (Basir 2022); postbiotics are also proposed to buffer acidic pH; no pooled estimate.
1 study
GRADE not reported

Salivary immunoglobulin A and pH · children aged 6 to 12 years

No meta-analysis was conducted; postbiotic toothpaste was reported to increase salivary immunoglobulin A and pH versus fluoride toothpaste.

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
4 weeks · clinical setting
no estimate extracted
1 study
GRADE not reported

Streptococcus mutans count · Humans at risk of dental caries (children aged 6-12 years; adults with dental caries)

Postbiotic products reduce salivary S. mutans counts in human trials, though not always significantly (ungraded narrative synthesis).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
Daily for 14 days to 4 weeks · Clinical; salivary/plaque sampling
Three RCTs reported reduced salivary S. mutans counts after postbiotic intervention; the reduction was statistically significant in Lin 2022 but non-significant in Basir 2022; no pooled estimate.
3 studies
GRADE not reported

Improved caries prognosis via restored oral microbiota · Patients after dental filling

Adjuvant postbiotics after dental filling improve caries prognosis by restoring the oral microbiota in one RCT (ungraded).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
14 days · Clinical; salivary/plaque sampling
One RCT reported that adjuvant postbiotic tablets after dental filling improved caries prognosis by restoring oral microbiota diversity, structure and function and reducing potentially pathogenic bacteria (Liu 2024);…
1 study
GRADE not reported