Postbiotic toothpaste vs Fluoride toothpaste alone: Increased salivary IgA
Postbiotics increase salivary IgA (immune modulation) in human trials (ungraded narrative synthesis).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Postbiotic toothpaste vs Fluoride toothpaste Increased salivary IgA · Children aged 6-12 years · Daily for 14 days to 4 weeks, Clinical; salivary/plaque sampling Postbiotics increase salivary IgA (immune modulation) in human trials (ungraded narrative synthesis). Postbiotics and Dental Caries: A Systematic Review. (2025) All outcomes | Postbiotic toothpaste significantly increased salivary IgA versus fluoride toothpaste (Basir 2022); the review also cites Lin 2022 for postbiotic immune modulation/IgA; no pooled estimate. | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes | October 2024 | 21 | Critically Low / Critically Low |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.