What do systematic reviews say?

Phenylephrine vs norepinephrine

It is very uncertain whether phenylephrine changes total mortalitya compared with norepinephrine (very low certainty).

• Vasopressors for hypotensive shock 2016 · Cochrane Headline outcomes only
  RR 1.08 [0.76, 1.55]
  2 studies · 86 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes ephedrine vs phenylephrine (very low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.92 [0.71, 1.18]
  8 studies · 401 participants
  Very low

Ephedrine vs phenylephrine

It is very uncertain whether ephedrine changes maternal hypotension requiring intervention compared with phenylephrine (very low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.92 [0.71, 1.18]
  8 studies · 401 participants
  Very low

Ephedrine vs phenylephrine

Ephedrine showed no clear difference in maternal hypertension requiring intervention compared with phenylephrine (low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 1.72 [0.71, 4.16]
  2 studies · 118 participants
  Low

Ephedrine vs phenylephrine

Ephedrine may leads to lower maternal bradycardia requiring intervention compared with phenylephrine (low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.37 [0.21, 0.64]
  5 studies · 304 participants
  Low

Ephedrine vs phenylephrine

It is very uncertain whether ephedrine changes maternal nausea and/or vomiting compared with phenylephrine (very low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.76 [0.39, 1.49]
  4 studies · 204 participants
  Very low

Ephedrine vs phenylephrine

Ephedrine showed no clear difference in neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 compared with phenylephrine (low certainty).

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  RR 0.89 [0.07, 12]
  3 studies · 175 participants
  Low

Ephedrine vs phenylephrine

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 321 participants
  Low

Ephedrine vs phenylephrine

The review found no eligible studies for this question.

• Techniques for preventing hypotension during spinal anaesthesia for caesarean section 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found