Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 3 reviews · Stroke · Headline outcomes only

No studies found 3 · 17.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 29.4%Moderate 3 · 17.6%High 6 · 35.3%

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Functional independence · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in functional independence at 3 months (mRS 0 to 2) (primary outcome) compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Successful reperfusion (mTICI 2b to 3) postprocedure · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in successful reperfusion (mTICI 2b to 3) postprocedure compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

All‐cause mortality within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in all‐cause mortality within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Intracranial hemorrhage on imaging at 24 hours · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in intracranial hemorrhage on imaging at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Symptomatic intracranial haemorrhage at · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in symptomatic intracranial hemorrhage at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Procedure‐related adverse events within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in procedure‐related adverse events within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Death or stroke · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in 30‐day post‐randomisation death/stroke compared with medical treatment alone (low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Fatal/non‐fatal stroke in the territory of the treated vertebral artery stenosis(assessed after 30 days post‐randomisation to completion of · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in fatal/non‐fatal stroke in the territory of the treated vertebral… compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Stroke (ischaemic or haemorrhagic)Median · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in stroke (ischaemic or haemorrhagic)Median compared with medical treatment alone (moderate certainty).

1 finding from 1 review