Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 35 findings · 4 reviews

No studies found 4 · 11.4%GRADE not reported 11 · 31.4%Very low 8 · 22.9%Low 11 · 31.4%Moderate 1 · 2.9%High 0 · 0%

Perazine vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether perazine changes acceptability of treatment Leaving the study early due to any reason compared with placebo (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Movement disorders number of participants receiving antiparkinson medication · patients with schizophrenia

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with other antipsychotics (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

Perazine showed no clear difference in overall tolerability Leaving the study early due to adverse events compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Satisfaction with care ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Quality of life ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs placebo

Global state change over time (no better or deterioration) · patients with schizophrenia

Perazine may leads to lower global state change over time (no better or deterioration) compared with placebo (low certainty).

1 finding from 1 review

Perazine vs placebo

Mental state: 2. Not improved (BPRS, < 30% decrease in BPRS score) · patients with schizophrenia

Perazine showed no clear difference in overall mental state less than 30% BPRS reduction compared with placebo (low certainty).

1 finding from 1 review

Perazine vs placebo

Movement disorders number of participants receiving antiparkinson medication · patients with schizophrenia

It is very uncertain whether perazine changes movement disorders number of participants receiving antiparkinson… compared with placebo (very low certainty).

1 finding from 1 review

Perazine vs placebo

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia
1 finding from 1 review
  • Perazine for schizophrenia 2014 · Cochrane Headline outcomes only
    no estimate extracted
    0 studies · 0 participants
    GRADE not reported

Perazine vs placebo

Satisfaction with care ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs placebo

Quality of life ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Global state change over time (no better or deterioration) · patients with schizophrenia

Perazine showed no clear difference in global state change over time (no better or deterioration) compared with other antipsychotics (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 1. General ‐ at least one adverse effect compared with low‐potency antipsychotic drugs (moderate certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 2.a. Specific ‐ movement disorders ‐ at least one… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review