Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 83 findings · 12 reviews

No studies found 29 · 34.9%GRADE not reported 7 · 8.4%Very low 34 · 41%Low 9 · 10.8%Moderate 4 · 4.8%High 0 · 0%

Pentoxifylline vs Spirulina

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether pentoxifylline changes burning sensation (VAS 0-100) compared with spirulina (very low certainty).

1 finding from 1 review

Pentoxifylline vs multivitamin and mineral supplement

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
    1 study · 29 participants
    GRADE not reported

Pentoxifylline vs Placebo or no active treatment

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline led to lower difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review

Pentoxifylline vs Placebo or no active treatment

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review