Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 46 findings · 5 reviews

No studies found 11 · 23.9%GRADE not reported 16 · 34.8%Very low 15 · 32.6%Low 2 · 4.3%Moderate 2 · 4.3%High 0 · 0%

PERPHENAZINE vs placebo

Global state: Change over time ‐ no better or deterioration ‐ short term clinically defined · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes global state: Change over time ‐ no better or deterioration ‐ short… compared with PLACEBO (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects dystonia ‐ short term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Other adverse events: any serious adverse event ‐ short and long term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes other adverse events: any serious adverse event ‐ short and long term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Service use and hospitalisation: admission ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Relapse · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes mental state: Relapse ‐ short term clinical diagnosis compared with PLACEBO (very low certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: death ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term compared with PLACEBO (very low certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: serious adverse events ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Economic outcome ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Service use and hospitalisation: admission ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Global state: Change over time ‐ no better or deterioration ‐ short and medium term as defined in each study · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes global state: Change over time ‐ no better or deterioration ‐ short… compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Mental state: State ‐ 'no effect' BPRS score reduction · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes mental state: State ‐ 'no effect' BPRS score reduction compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Risk for at least one adverse event per patient · patients with schizophrenia

Comparison 1: PERPHENAZINE showed no clear difference in adverse effects ‐ at least one adverse effect compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (low certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Comparison 1: PERPHENAZINE showed no clear difference in adverse effects ‐ movement disorders ‐ at least one movement disorder compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (low certainty).

1 finding from 1 review