Findings

What do systematic reviews say?

9 questions · 9 findings · 3 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 33.3%Low 1 · 11.1%Moderate 2 · 22.2%High 3 · 33.3%

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).

1 finding from 1 review

Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.02 [0.89, 1.18]
10 studies · 1066 participants
High

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only
RR 0.94 [0.87, 1.01]
8 studies · 958 participants
High

Inhaled NO vs control

Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.2 [0.98, 1.47]
6 studies · 773 participants
High

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry before 3 days… compared with control (moderate certainty).

1 finding from 1 review

Inhaled nitric oxide for respiratory failure in preterm infants 2017 · Cochrane Headline outcomes only
RR 1.05 [0.78, 1.4]
2 studies · 208 participants
Moderate

Sildenafil vs placebo

Change in oxygenation index ‐ After 24 hours of treatment · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Low

Prone vs lateral

Oxygenation SpO2a · neonates with mechanical ventilation

1 finding from 1 review

Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 206 participants
Very low

Lateral vs supine

Oxygenation SpO21 · neonates with mechanical ventilation

1 finding from 1 review

Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 206 participants
Very low

Prone vs supine

Oxygenation: PO2 (mmHg)a · neonates with mechanical ventilation

1 finding from 1 review

Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 116 participants
Moderate

Prone vs supine

Oxygenation: SpO2e · neonates with mechanical ventilation

1 finding from 1 review

Infant position in neonates receiving mechanical ventilation 2016 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 308 participants
Very low