Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

37 questions · 37 findings · 3 reviews · Epilepsy

No studies found 3 · 8.1%GRADE not reported 4 · 10.8%Very low 10 · 27%Low 11 · 29.7%Moderate 8 · 21.6%High 1 · 2.7%

Osmotic‐release oral system methylphenidate vs placebo

Proportion of individuals withdrawing from treatment · people with ADHD and epilepsy

Osmotic‐release oral system methylphenidate probably leads to higher proportion of people withdrawing from treatment compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events (28 weeks trial period) · Patients between five and 15 years old with a diagnosis of BECTS

The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events (96 weeks trial period) · Patients with a clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who discontinued treatment due to adverse… (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who discontinued treatment due to adverse events ( · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS

The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients who are seizure free between 4‐40 weeks · Patients with a clinical and EEG diagnosis of BECTS

It is very uncertain whether the intervention changes proportion of patients who are seizure free between 4‐40 weeks (very low certainty).

1 finding from 1 review