Other adverse effects (taste disturbance, oral mucosal effects, burning sensation) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
1 finding from 1 review
Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir led to lower number of individuals with oral lesions (8 days after… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Duration and time of healing of extraoral lesions; development of new extraoral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir led to lower number of individuals who developed new extraoral lesions after… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Supragingival calculus formation (various calculus indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… showed no clear difference in supragingival calculus formation (various calculus indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.
3 findings from 1 review
SMD 0.02 [-0.09, 0.14]
2 studies · 102 participants
GRADE not reported
SMD 0.32 [-0.04, 0.69]
6 studies · 425 participants
GRADE not reported
SMD 0.80 [0.33, 1.26]
4 studies · 323 participants
GRADE not reported
Gingivitis · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… leads to lower gingivitis (gingival inflammation) measured by Gingival Index of Loe… compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral… (high certainty).
2 findings from 1 review
Gingival bleeding (various bleeding indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… led to lower gingival bleeding (various bleeding indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.
2 findings from 1 review
Plaque · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… leads to lower dental plaque (various plaque indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral… (high certainty).
2 findings from 1 review
Extrinsic tooth staining (various staining indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… led to higher extrinsic tooth staining (various staining indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.
2 findings from 1 review
Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.
1 finding from 1 review
Probing pocket depth · Adults in case-control studies (oral cancer patients vs healthy controls)
Periodontal pocket depth did not differ significantly between oral cancer patients and controls (SMD 1.64, 95% CI -0.20 to 3.47; very high heterogeneity); ungraded.
1 finding from 1 review
Alveolar bone loss · Adults in case-control studies (oral cancer patients vs healthy controls)
Alveolar bone loss did not differ significantly between oral cancer patients and controls (SMD 0.18, 95% CI -2.34 to 2.69; extreme heterogeneity); ungraded.
1 finding from 1 review
Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)
The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.
1 finding from 1 review
Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
The mean number of missing teeth did not differ significantly between oral cancer patients and controls (SMD 0.59, 95% CI -0.04 to 1.22); ungraded.
1 finding from 1 review
Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)
Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.
1 finding from 1 review
Self-reported tooth brushing · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Stewart 1991: for self reported brushing only the comparison of the control group with the cognitive behavioural intervention was significant; the cognitive behavioural (psychological) intervention showed no…
1 study · 50 participants
GRADE not reported
Plaque · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Stewart 1991: while the educational intervention group and the cognitive behavioural intervention group both showed significant differences compared to the control group in plaque scores, the cognitive behavioural…
1 study · 50 participants
GRADE not reported
Self-reported flossing · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Stewart 1991: there were no differences between the educational intervention group and the cognitive behavioural (psychological) intervention group for self reported flossing; improvements in flossing could not be…
1 study · 50 participants
GRADE not reported
Dental knowledge · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Stewart 1996: there was no difference in change in dental knowledge at post-intervention between the educational and psychological groups (both improved significantly relative to control).
1 study · 78 participants
GRADE not reported
Self-efficacy beliefs (flossing) · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Stewart 1996: the psychological intervention group demonstrated significantly higher change in self efficacy scores for flossing at post-intervention compared to the educational group (there was no difference in the…
1 study · 78 participants
GRADE not reported
Oral microbiota composition · Individuals assessed for oral microbiota (mainly children and adolescents)
Oral microbiota composition differs between persons with orofacial cleft and healthy controls, synthesized qualitatively across 8 studies but not meta-analyzed (ungraded).
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported