Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Gut

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%

Supplementary analgesic option offered (primary outcome 2) · participants with acute pancreatitis pain

Opioids may leads to lower supplementary analgesic option offered (primary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 0.41 [0.29, 0.57]
3 studies · 162 participants
Low

Pancreatitis complications (secondary outcome 1) · participants with acute pancreatitis pain

Opioids showed no clear difference in pancreatitis complications (secondary outcome 1) compared with no opioids (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 1.05 [0.82, 1.34]
3 studies · 162 participants
Low

Adverse drug events · participants with acute pancreatitis pain

Opioids showed no clear difference in any drug‐related adverse event (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 2 [0.9, 4.46]
2 studies · 110 participants
Low

Nausea and vomiting · participants with acute pancreatitis pain

Opioids showed no clear difference in nausea and vomiting (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 1.68 [0.7, 4]
2 studies · 55 participants
Low

Sedation and somnolence (secondary outcome 2) · participants with acute pancreatitis pain

Opioids showed no clear difference in sedation and somnolence (secondary outcome 2) compared with no opioids (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 5.54 [0.69, 44.79]
2 studies · 55 participants
Low

Death from any cause (secondary outcome 3) · participants with acute pancreatitis pain

It is very uncertain whether opioids changes death from any cause (secondary outcome 3) compared with no opioids (very low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 0.35 [0.02, 8.1]
4 studies · 194 participants
Very low

Improvements in pain intensity as defined by the trialist (primary outcome) · participants with acute pancreatitis pain

Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 0.5 [0.19, 1.33]
1 study · 16 participants
Low