Cochrane · systematic review · CD009179
Opioids for acute pancreatitis pain
Basurto Ona, X, Rigau Comas, D, Urrútia, G · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Morphine compared to metamizole for acute pancreatitis pain
Population: participants with acute pancreatitis pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvements in pain intensity as defined by the trialist (primary outcome) Morphine vs metamizole | RR 0.5 [0.19, 1.33] | 1 study · 16 participants | Low Downgraded: risk of bias, imprecision |
Opioids versus no opioids for acute pancreatitis pain
Population: participants with acute pancreatitis pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Supplementary analgesic option offered (primary outcome 2) Opioids vs no opioids | RR 0.41 [0.29, 0.57] | 3 studies · 162 participants | Low Downgraded: risk of bias |
Pancreatitis complications (secondary outcome 1) Opioids vs no opioids | RR 1.05 [0.82, 1.34] | 3 studies · 162 participants | Low Downgraded: risk of bias |
Any drug‐related adverse event (secondary outcome 2) Opioids vs no opioids | RR 2 [0.9, 4.46] | 2 studies · 110 participants | Low Downgraded: risk of bias |
Nausea and vomiting (secondary outcome 2) Opioids vs no opioids | RR 1.68 [0.7, 4] | 2 studies · 55 participants | Low Downgraded: risk of bias |
Sedation and somnolence (secondary outcome 2) Opioids vs no opioids | RR 5.54 [0.69, 44.79] | 2 studies · 55 participants | Low Downgraded: risk of bias |
Death from any cause (secondary outcome 3) Opioids vs no opioids | RR 0.35 [0.02, 8.1] | 4 studies · 194 participants | Very low Downgraded: risk of bias |