Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 55 findings · 12 reviews · Haematology

No studies found 17 · 30.9%GRADE not reported 2 · 3.6%Very low 13 · 23.6%Low 12 · 21.8%Moderate 8 · 14.5%High 3 · 5.5%

Summary of Findings Table ‐ Enoxaparin vs no enoxaparin

Adverse events: clinically relevant non‐major bleeding / heparin‐induced thrombocytopenia ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Bortezomib vs no bortezomib

Thrombocytopenia · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Thrombocytopenia compared with no bortezomib (low certainty).

3 findings from 1 review

Ruxolitinib vs best available therapy

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib showed no clear difference in safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with best available therapy (low certainty).

1 finding from 1 review

Ruxolitinib vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · Patients with treating MF

Ruxolitinib may leads to higher safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Episodes of febrile neutropenia · patients with prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in episodes of febrile neutropenia (moderate certainty).

1 finding from 1 review