Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 3 · 50%Very low 2 · 33.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Older adults with anticholinergic burden vs older adults with no anticholinergic burden · Cognitive decline or dementia
  Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no… 2021 · Cochrane Headline outcomes only
  OR 2.63 [1.09, 6.29]
  4 studies · 125359 participants
  Low
Direct match · question page
- Anticholinergic burden reduction interventions vs usual care · Cognitive decline
  Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 299 participants
  Very low
Direct match · question page
- Anticholinergic burden reduction interventions vs usual care · Incidence of clinical dementia
  Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported
Related
- · Cognitive decline
  Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 18213 participants
  Very low
Related
- · Neuropsychiatric outcomes
  Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Older adults with anticholinergic burden vs older adults with no anticholinergic burden

Cognitive decline or dementia · older adults without cognitive impairment at baseline

Older adults with anticholinergic burden may leads to higher cognitive decline or dementia compared with older adults with no anticholinergic burden (low certainty).

1 finding from 1 review

Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no… 2021 · Cochrane Headline outcomes only
OR 2.63 [1.09, 6.29]
4 studies · 125359 participants
Low

Anticholinergic burden reduction interventions vs usual care

Cognitive decline · older adults with and without prior cognitive impairment

1 finding from 1 review

Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 299 participants
Very low

Anticholinergic burden reduction interventions vs usual care

Incidence of dementia · older adults with and without prior cognitive impairment

1 finding from 1 review

Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Anticholinergic burden reduction interventions vs usual care

Adverse effects · older adults with and without prior cognitive impairment

1 finding from 1 review

Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Cognitive decline · older adults with cognitive impairment at baseline

1 finding from 1 review

Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild… 2022 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 18213 participants
Very low

Intervention not reported

Neuropsychiatric outcomes · older adults with cognitive impairment at baseline

1 finding from 1 review

Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild… 2022 · Cochrane Headline outcomes only
no estimate extracted
0 participants
GRADE not reported