Cochrane · systematic review · CD015405
Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with and without prior cognitive impairment
Taylor-Rowan, M, Alharthi, AA, Noel-Storr, AH, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
1
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticholinergic burden reduction interventions compared to usual care for cognitive outcomes in older adults with and without prior cognitive impairment
Population: older adults with and without prior cognitive impairment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive decline Anticholinergic burden reduction interventions vs usual care | no estimate extracted | 3 studies · 299 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Incidence of clinical dementia Anticholinergic burden reduction interventions vs usual care | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effects Anticholinergic burden reduction interventions vs usual care | no estimate extracted | 0 studies · 0 participants | Ungraded |