What do systematic reviews say?

OS‐LE vs S‐LE

OS‐LE showed no clear difference in death before discharge(incidence) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1 [0.21, 4.82]
  3 studies · 224 participants
  Low

OS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 223 participants
  Low

OS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 123 participants
  Low

OS‐LE vs S‐LE

It is very uncertain whether OS‐LE changes bronchopulmonary dysplasia/chronic lung disease (incidence ‐… compared with S‐LE (very low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.69 [0.46, 1.04]
  4 studies · 261 participants
  Very low

OS‐LE vs S‐LE

OS‐LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease (sensitivity analysis) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.01 [0.57, 1.79]
  3 studies · 197 participants
  Low

OS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 202 participants
  Very low

OS‐LE vs S‐LE

It is very uncertain whether OS‐LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 0.87 [0.56, 1.36]
  5 studies · 301 participants
  Very low

Alternative lipid emulsion (LE) vs S‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 123 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.26, 3.86]
  4 studies · 261 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.15, 6.82]
  2 studies · 159 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in death before discharge – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.21, 4.82]
  3 studies · 224 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

It is very uncertain whether alternative lipid emulsion (LE) changes any ROP – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (very low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.98 [0.67, 1.43]
  3 studies · 142 participants
  Very low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in any BPD – OS‐LE vs S‐LE (sensitivity analysis) compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.01 [0.57, 1.79]
  3 studies · 197 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in culture‐positive sepsis – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.22 [0.54, 2.78]
  2 studies · 164 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 310 participants
  Low

Alternative lipid emulsion (LE) vs another alternative‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 2.9 [0.12, 68.5]
  1 study · 59 participants
  Low

Alternative lipid emulsion (LE) vs another alternative‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  GRADE not reported

Alternative lipid emulsion (LE) vs another alternative‐LE

Alternative lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MS‐LE vs… compared with another alternative‐LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.77 [0.23, 2.6]
  1 study · 59 participants
  Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Alternative lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.93 [0.65, 5.73]
  1 study · 59 participants
  Low