Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 1 reviews · Heart · Headline outcomes only

No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 6 · 37.5%Low 3 · 18.8%Moderate 5 · 31.3%High 0 · 0%

PCC vs FVIIa

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · cardiac surgery for the treatment of non‐surgical bleeding

It is very uncertain whether PCC changes thrombotic events compared with FVIIa (very low certainty).

1 finding from 1 review

PCC vs usual care

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · cardiac surgery for the treatment of non‐surgical bleeding

PCC showed no clear difference in thrombotic events compared with standard treatment (moderate certainty).

1 finding from 1 review