Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 50 findings · 2 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 13 · 26%Very low 16 · 32%Low 14 · 28%Moderate 7 · 14%High 0 · 0%

Non‐invasive ventilation vs supplemental oxygen or no treatment

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes need for mechanical ventilation compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes need for mechanical ventilation ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Endotracheal intubation To discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

It is very uncertain whether nHFV changes endotracheal intubation To discharge compared with nIPPV following failure of initial non‐invasive respiratory support (very low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in chronic lung disease compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Duration of tachypnea, defined as hours with respiratory rate greater than 60 breaths per minute · patients with the management of transient tachypnea of the newborn
2 findings from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Pneumothorax · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes pneumothorax ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review