Findings

What do systematic reviews say?

21 questions · 21 findings · 2 reviews · Breast Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 9.5%Low 13 · 61.9%Moderate 4 · 19%High 2 · 9.5%

No axillary surgery vs full axillary surgery

All‐cause mortality · women with operable primary breast cancer

No axillary surgery showed no clear difference in all‐cause mortality compared with full axillary surgery (moderate certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 1.06 [0.96, 1.17]
10 studies · 3849 participants
Moderate

No axillary surgery vs full axillary surgery

Locoregional recurrence · women with operable primary breast cancer

No axillary surgery probably leads to higher locoregional recurrence compared with full axillary surgery (moderate certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 2.35 [1.91, 2.89]
5 studies · 20863 participants
Moderate

No axillary surgery vs full axillary surgery

Lymphoedema Increase in arm circumference · women with operable primary breast cancer

No axillary surgery may leads to lower lymphoedema Increase in arm circumference compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.31 [0.23, 0.43]
4 studies · 1714 participants
Low

No axillary surgery vs full axillary surgery

Arm or shoulder movement impairment · women with operable primary breast cancer

It is very uncertain whether no axillary surgery changes arm or shoulder movement impairment compared with full axillary surgery (very low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.72 [0.49, 1.05]
5 studies · 1495 participants
Very low

Axillary sampling vs full axillary surgery

All‐cause mortality · women with operable primary breast cancer

Axillary sampling showed no clear difference in all‐cause mortality compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 0.94 [0.73, 1.21]
3 studies · 967 participants
Low

Axillary sampling vs full axillary surgery

Local recurrence · women with operable primary breast cancer

Axillary sampling showed no clear difference in local recurrence compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 1.41 [0.94, 2.12]
3 studies · 1404 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Incidence of postoperativeseromaRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in incidence of postoperativeseromaRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.02 [0.9, 1.16]
18 studies · 1252 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Mean volume of seromaSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 731 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Total volume of drained seromaSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 888 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Number of days for persistent drainageSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 861 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Surgical site infection · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in surgical site infectionRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.05 [0.63, 1.77]
13 studies · 1009 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

PostoperativecomplicationsRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in postoperativecomplicationsRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.13 [0.63, 2.04]
11 studies · 981 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Length of hospital stay (theoretical) · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 364 participants
Low

Sentinel node biopsy vs full axillary surgery

Paraesthesia · women with operable primary breast cancer

Sentinel node biopsy may leads to lower paraesthesia compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.15 [0.09, 0.23]
2 studies · 495 participants
Low

Sentinel node biopsy vs full axillary surgery

Pain · women with operable primary breast cancer

Sentinel node biopsy may leads to lower pain compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.44 [0.3, 0.67]
2 studies · 877 participants
Low

Sentinel node biopsy vs full axillary surgery

Numbness · women with operable primary breast cancer

Sentinel node biopsy probably leads to lower numbness compared with full axillary surgery (moderate certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.43 [0.34, 0.54]
3 studies · 1799 participants
Moderate

Radiotherapy vs full axillary surgery

All‐cause mortality · women with operable primary breast cancer

Radiotherapy alone showed no clear difference in all‐cause mortality compared with full axillary surgery (high certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 1.1 [1, 1.21]
4 studies · 2469 participants
High

Radiotherapy vs full axillary surgery

Local recurrence · women with operable primary breast cancer

Radiotherapy alone leads to lower local recurrence compared with full axillary surgery (high certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 0.8 [0.64, 0.99]
4 studies · 22256 participants
High

Sentinel node biopsy vs full axillary surgery

All‐cause mortality · women with operable primary breast cancer

Sentinel node biopsy showed no clear difference in all‐cause mortality compared with full axillary surgery (moderate certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
HR 1.05 [0.89, 1.25]
3 studies · 6352 participants
Moderate

Sentinel node biopsy vs full axillary surgery

Lymphoedema Patient‐reported lymphoedema of any severity · women with operable primary breast cancer

Sentinel node biopsy may leads to lower lymphoedema Patient‐reported lymphoedema of any severity compared with full axillary surgery (low certainty).

1 finding from 1 review

Axillary treatment for operable primary breast cancer 2017 · Cochrane Headline outcomes only
OR 0.33 [0.15, 0.86]
3 studies · 815 participants
Low