Findings

What do systematic reviews say?

324 questions · 328 findings · 34 reviews · Headline outcomes only

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No studies found 82 · 25%GRADE not reported 8 · 2.4%Very low 75 · 22.9%Low 105 · 32%Moderate 45 · 13.7%High 13 · 4%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- NSAIDs vs placebo · Pain: ≥ 50% improvement in pain (spontaneous pain at 24 hours)
  Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  RR 2.75 [1.13, 6.72]
  Studies not reported
  Low
Direct match · question page
- NSAIDs vs paracetamol · Adverse events
  Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 1.71 [0.43, 6.9]
  3 studies · 281 participants
  Very low
Direct match · question page
- NSAIDs vs glucocorticoids · Pain: mean decrease per hour on a VAS scale (0 to 100, 0 no pain)
  Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate
Direct match · question page
- NSAIDs vs paracetamol · Mean time to resolution of pain
  Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
Direct match · question page
- NSAIDs vs placebo · Mean time to resolution of pain
  Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical NSAIDs vs topical placebo

All topical NSAIDs Local adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 6125 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Systemic adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
38 studies · 5372 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Withdrawals ‐ adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 5790 participants
High

NSAIDs vs placebo

to 72 hours (48 hours)

NSAIDs may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.28 [0.11, 0.7]
1 study · 146 participants
Low

NSAIDs vs placebo

to 7 days

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.76 [0.44, 7.1]
1 study · 146 participants
Very low

NSAIDs vs placebo

Mean time to resolution of pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Mean pain score at various time points

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Reconsultations

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Delayed antibiotic prescriptions

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs paracetamol

hours

It is very uncertain whether NSAIDs changes hours compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.83 [0.59, 1.18]
2 studies · 39 participants
Very low

NSAIDs vs paracetamol

to 72 hours

NSAIDs showed no clear difference in to 72 hours compared with paracetamol (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.91 [0.54, 1.54]
3 studies · 183 participants
Low

NSAIDs vs paracetamol

to 7 days

It is very uncertain whether NSAIDs changes to 7 days compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.74 [0.17, 3.23]
2 studies · 38 participants
Very low

NSAIDs vs paracetamol

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.71 [0.43, 6.9]
3 studies · 281 participants
Very low

NSAIDs vs paracetamol

Mean time to resolution of pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs paracetamol

Reconsultations

It is very uncertain whether NSAIDs changes reconsultations compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.13 [0.92, 1.4]
1 study · 53 participants
Very low

NSAIDs vs paracetamol

Delayed antibiotic prescriptions

It is very uncertain whether NSAIDs changes delayed antibiotic prescriptions compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.32 [0.74, 2.35]
1 study · 53 participants
Very low

NSAIDs vs placebo

hours

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Participant‐reported pain relief of 50% or greater · acute gout

NSAIDs may leads to higher pain: ≥ 50% improvement in pain (spontaneous pain at 24 hours) compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 2.75 [1.13, 6.72]
Studies not reported
Low

NSAIDs vs glucocorticoids

Pain: mean decrease per hour on a VAS scale (0 to 100, 0 no pain) · acute gout

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate