What do systematic reviews say?

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in misoprostol in abdominal myomectomy compared with placebo or no treatment (moderate certainty).

• Interventions to reduce haemorrhage during myomectomy for fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Moderate

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in misoprostol in laparoscopic myomectomy compared with placebo or no treatment (moderate certainty).

• Interventions to reduce haemorrhage during myomectomy for fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 232 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; unscheduled return to… compared with open myomectomy (all types) (low certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 3.04 [0.12, 75.86]
  2 studies · 188 participants
  Low

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; laparoconversion compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 1.11 [0.44, 2.83]
  8 studies · 756 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; injury to pelvic organs compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 3.04 [0.12, 75.86]
  1 study · 148 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy probably leads to lower in‐hospital adverse events; postoperative fever compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 0.44 [0.26, 0.77]
  6 studies · 635 participants
  Moderate

Myomectomy vs no treatment

The review found no eligible studies for this question.

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes miscarriage Rate ‐ Intramural/Subserous compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 0.8 [0.1, 6.54]
  1 study · 31 participants
  Very low

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes miscarriage Rate ‐ Intramural/Submucous compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 2 [0.32, 12.33]
  1 study · 42 participants
  Very low

Myomectomy vs no treatment

The review found no eligible studies for this question.

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myomectomy vs no treatment

The review found no eligible studies for this question.

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes clinical pregnancy rate ‐ Intramural compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 1.88 [0.57, 6.14]
  1 study · 45 participants
  Very low

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes clinical pregnancy rate ‐ Submucous compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 2.04 [0.62, 6.66]
  1 study · 52 participants
  Very low

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes clinical pregnancy rate ‐ Intramural/Subserous compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 2 [0.4, 10.09]
  1 study · 31 participants
  Very low

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes clinical pregnancy rate ‐ Intramural/Submucous compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 3.24 [0.72, 14.57]
  1 study · 42 participants
  Very low

Myomectomy vs no treatment

The review found no eligible studies for this question.

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Myomectomy vs no treatment

It is very uncertain whether myomectomy changes miscarriage Rate ‐ Intramural compared with no treatment (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 1.33 [0.26, 6.78]
  1 study · 45 participants
  Very low