Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

61 questions · 61 findings · 14 reviews · Neuromuscular

No studies found 21 · 34.4%GRADE not reported 2 · 3.3%Very low 18 · 29.5%Low 11 · 18%Moderate 9 · 14.8%High 0 · 0%

Brain‐derived neurotrophic factor vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether brain‐derived neurotrophic factor changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Cerebrospinal fluid filtration vs plasma exchange

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether cerebrospinal fluid filtration changes participants with 1 or more serious adverse events compared with plasma exchange (very low certainty).

1 finding from 1 review

Eculizumab vs placebo

Participants with 1 or more serious adverse events · adults with severe Guillain‐Barré syndrome (GBS disability score > 2), within 2 weeks form onset

Eculizumab showed no clear difference in participants with 1 or more serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Interferon beta‐1a vs placebo

Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome

It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Botulinum toxin plus conservative treatment vs conservative treatment

Improvement (greater than 50% of time spent) heel‐toe walking Measured by parents' perception of toe walking frequency more than 50% of the time. · children with ITW gait

It is very uncertain whether botulinum toxin plus conservative treatment changes improvement (greater than 50% of time spent) heel‐toe walking… compared with conservative treatment only (very low certainty).

1 finding from 1 review

Acupuncture vs gastrokinetic agents

Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) · symptomatic gastroparesis

It is very uncertain whether acupuncture changes proportion of people whose symptoms 'improved' (long term: more than… compared with gastrokinetic agents (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis

The review found no eligible studies for this question.

1 finding from 1 review