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Evidence found and GRADE certainty

330 questions · 337 findings · 33 reviews

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No studies found 96 · 28.5%GRADE not reported 53 · 15.7%Very low 80 · 23.7%Low 63 · 18.7%Moderate 39 · 11.6%High 6 · 1.8%

Central monitoring with triggered vs untriggered on‐site visits

Sites ≥ 1 major monitoring finding combined outcome · clinical trials in all fields of health care

Central monitoring with triggered showed no clear difference in sites ≥ 1 major monitoring finding combined outcome compared with untriggered on‐site visits (low certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Central and local monitoring only probably leads to higher combined outcome of proportion of participants with major or… compared with central and local monitoring with on‐site visits (moderate certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Impact of the monitoring strategy on · clinical trials in all fields of health care

It is very uncertain whether central and local monitoring only changes impact of the monitoring strategy on compared with central and local monitoring with on‐site visits (very low certainty).

1 finding from 1 review

Self‐monitoring vs a different type of self‐monitoring

Perinatal mortality · women with pre‐existing diabetes

It is very uncertain whether self‐monitoring changes perinatal mortality (stillbirth and neonatal mortality) compared with a different type of self‐monitoring (very low certainty).

1 finding from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care

Death (all causes) · patients with heart failure

Summary of findings ‐ structured telephone support or telemonitoring probably leads to lower all‐cause mortality: Telemonitoring versus usual care compared with usual care ‐ all‐cause mortality (moderate certainty).

1 finding from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care ‐ all‐cause hospitalisation

Hospitalisation (any cause) · patients with heart failure

It is very uncertain whether summary of findings ‐ structured telephone support or telemonitoring changes all‐cause hospitalisation: Structured telephone support verus usual… compared with usual care ‐ all‐cause hospitalisation (very low certainty).

2 findings from 1 review

Summary of findings ‐ structured telephone support or telemonitoring vs usual care

Heart failure hospitalisation (RR) · patients with heart failure

Summary of findings ‐ structured telephone support or telemonitoring probably leads to lower CHF‐related hospitalisation: Structured telephone support versus… compared with usual care ‐ heart failure‐related hospitalisation (moderate certainty).

2 findings from 1 review