Findings

What do systematic reviews say?

29 questions · 30 findings · 5 reviews

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No studies found 5 · 16.7%GRADE not reported 12 · 40%Very low 2 · 6.7%Low 11 · 36.7%Moderate 0 · 0%High 0 · 0%

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Proportion of participants with adverse event · Participants with rosacea

Minocycline 45 mg showed no clear difference in proportion of participants with adverse event compared with minocycline 45 mg + azelaic acid gel (low certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 0.69 [0.39, 1.22]
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Time needed until improvement · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

3Mix (ciprofloxacin + metronidazole + minocycline) vs Ciprofloxacin + ornidazole + minocycline

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
Listed as a pulpectomy comparison; no extractable outcome data reported in this version
0 studies
No studies found

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Plaque · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in plaque compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: maintaining and recovering soft tissue health around dental implants 2010 · Cochrane All outcomes
12 months
MD 6.00 [-9.07, 21.07]
1 study · 32 participants
GRADE not reported

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: maintaining and recovering soft tissue health around dental implants 2010 · Cochrane All outcomes
12 months
MD 0.30 [-0.17, 0.77]
1 study · 32 participants
GRADE not reported

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (worst sites) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: maintaining and recovering soft tissue health around dental implants 2010 · Cochrane All outcomes
12 months
MD 0.40 [-0.28, 1.08]
1 study · 32 participants
GRADE not reported

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: maintaining and recovering soft tissue health around dental implants 2010 · Cochrane All outcomes
12 months
RR 5.00 [0.66, 38.15]
1 study · 32 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) vs simvastatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether 3Mix (ciprofloxacin + metronidazole + minocycline) changes clinical failure compared with simvastatin (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.51, 1.95]
1 study · 160 participants
Very low

3Mix (ciprofloxacin + metronidazole + minocycline) vs simvastatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) vs 3Mixtatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) may leads to higher clinical failure compared with 3Mixtatin (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.00 [1.22, 13.11]
1 study · 160 participants
Low

3Mix (ciprofloxacin + metronidazole + minocycline) vs 3Mixtatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 5.00 [0.25, 99.95]
1 study · 60 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in radiological failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 11.00 [0.64, 190.53]
1 study · 60 participants
GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

1 finding from 1 review

Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
12 months
OR 0.45 [0.14, 1.52]
1 study · 50 participants
Very low