Findings

What do systematic reviews say?

20 questions · 21 findings · 2 reviews

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No studies found 1 · 4.8%GRADE not reported 0 · 0%Very low 3 · 14.3%Low 13 · 61.9%Moderate 3 · 14.3%High 1 · 4.8%

MgSO4 vs SABA

Lung function · adults and children with acute exacerbation of asthma

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

MgSO4 vs SABA

Clinical severity score ‐ Fischl index (120 minutes) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Very low

MgSO4 vs SABA

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

It is very uncertain whether mgSO4 changes admission to hospital at initial presentation compared with SABA (very low certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 0.53 [0.05, 5.31]
1 study · 33 participants
Very low

MgSO4 vs SABA

Serious adverse events (During ED/hospital admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
Low

MgSO4 vs placebo

Hospital admissions · children with acute asthma in the emergency department

MgSO4 may leads to lower hospital admissions compared with placebo (low certainty).

1 finding from 1 review

Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
OR 0.32 [0.14, 0.74]
3 studies · 115 participants
Low

MgSO4 vs placebo

ED treatment duration (minutes) · children with acute asthma in the emergency department

1 finding from 1 review

Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

MgSO4 vs placebo

Return to ED within 48 hours · children with acute asthma in the emergency department

MgSO4 showed no clear difference in return to ED within 48 hours compared with placebo (low certainty).

1 finding from 1 review

Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
OR 0.4 [0.02, 10.3]
2 studies · 85 participants
Low

MgSO4 vs placebo

Length of hospital stay · children with acute asthma in the emergency department

1 finding from 1 review

Intravenous magnesium sulfate for treating children with acute asthma in the emergency department 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Low

MgSO4 + SABA vs SABA

PEF (L/min) · adults and children with acute exacerbation of asthma

2 findings from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Low
Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 155 participants
Low

MgSO4 + SABA vs SABA

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

MgSO4 + SABA showed no clear difference in admission to hospital at initial presentation compared with SABA (low certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 0.78 [0.52, 1.15]
6 studies · 375 participants
Low

MgSO4 + SABA vs SABA

Serious adverse events (During ED/hospital admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 243 participants
Low

MgSO4 + SABA vs SABA

Any adverse events (During ED/hospital admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 694 participants
Low

MgSO4 + SABA vs SABA

FEV1 % predicted · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 208 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

FEV1 · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 120 participants
Very low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Pulmonary function % predicted PEF (60 minutes) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 636 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Clinical severity scores (60 minutes) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1130 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

MgSO4 + SABA + ipratropium showed no clear difference in admission at first presentation compared with SABA + ipratropium (moderate certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 0.95 [0.91, 1]
4 studies · 1308 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Patient readmissions · adults and children with acute exacerbation of asthma

MgSO4 + SABA + ipratropium showed no clear difference in readmission (7 to 30 days) compared with SABA + ipratropium (low certainty).

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
RR 1.8 [0.84, 3.87]
2 studies · 750 participants
Low

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Serious adverse events (during admission) · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 557 participants
Moderate

MgSO4 + SABA + ipratropium vs SABA + ipratropium

Adverse effects Defined as any adverse event occurring post‐admission · adults and children with acute exacerbation of asthma

1 finding from 1 review

Inhaled magnesium sulfate in the treatment of acute asthma 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1197 participants
High