Findings

What do systematic reviews say?

9 questions · 9 findings · 2 reviews · Pain, Palliative and Supportive Care

No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 7 · 77.8%Low 1 · 11.1%Moderate 0 · 0%High 0 · 0%

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with cancer pain

Methadone may leads to higher participant‐reported pain intensity compared with morphine (low certainty).

1 finding from 1 review

Methadone for cancer pain 2017 · Cochrane Headline outcomes only
OR 76
103 participants
Low

Adverse events: appetite, thirst, somnolence · people with cancer pain

1 finding from 1 review

Methadone for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 342 participants
Very low

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 29 participants
Very low

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Lack of efficacy withdrawal · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 29 participants
Very low

Withdrawals due to adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 29 participants
Very low

Participants experiencing anyserious adverseevents · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Deaths · adults with chronic neuropathic pain

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

CI: Confidence interval · adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Methadone for neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found