Death (any cause) (median · hospitalised adult patients
Medication review showed no clear difference in mortality (all‐cause) Median compared with standard care (low certainty).
1 finding from 1 review
Hospital readmission · hospitalised adult patients
Medication review probably leads to lower hospital readmission (all‐cause) Median compared with standard care (moderate certainty).
1 finding from 1 review
ED visits · hospitalised adult patients
Medication review showed no clear difference in hospital emergency department contacts (all‐cause) Median compared with standard care (low certainty).
1 finding from 1 review
Health‐related quality of lifeg Median · hospitalised adult patients
It is very uncertain whether medication review changes health‐related quality of lifeg Median compared with standard care (very low certainty).
1 finding from 1 review
Rate of falls Length of · and
1 finding from 1 review
Risk of falling Length of · and
Summary of findings: General medication review showed no clear difference in risk of falling Length of compared with usual care (low certainty).
1 finding from 1 review
Risk of fracture Length of · and
It is very uncertain whether summary of findings: General medication review changes risk of fracture Length of compared with usual care (very low certainty).
1 finding from 1 review
Adverse events Length of · and
It is very uncertain whether summary of findings: General medication review changes adverse events Length of compared with usual care (very low certainty).
1 finding from 1 review
Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).
1 finding from 1 review
Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)
Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).
1 finding from 1 review
Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.29 [0.58, 2.88]
Studies not reported
Very low
Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.02]
Studies not reported
Very low
Parotid hypertrophy prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Parotid hypertrophy was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.01 [0.00, 0.05]
Studies not reported
Very low
Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)
A single small study suggested delayed dental development in CLWH on ART, but the evidence was insufficient to draw conclusions (very low certainty).
1 finding from 1 review
Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)
Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.73 [0.13, 4.26]
0 studies
GRADE not reported
Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucocele between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.02 [0.00, 1.09]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).
1 finding from 1 review
OR 0.35 [0.24, 0.51]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).
1 finding from 1 review
Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in angular cheilitis between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.58 [0.17, 1.99]
Studies not reported
Very low
Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.03 [0.02, 0.07]
Studies not reported
Very low