Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

28 questions · 28 findings · 4 reviews

No studies found 0 · 0%GRADE not reported 2 · 7.1%Very low 21 · 75%Low 4 · 14.3%Moderate 1 · 3.6%High 0 · 0%

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)

Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Parotid hypertrophy prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Parotid hypertrophy was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)

A single small study suggested delayed dental development in CLWH on ART, but the evidence was insufficient to draw conclusions (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)

Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in mucocele between CLWH with and without ART (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs No antiretroviral medication (treatment-naive)

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).

1 finding from 1 review

Monotherapy or dual antiretroviral therapy vs No antiretroviral medication (treatment-naive)

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in angular cheilitis between CLWH with and without ART (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review