Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

231 questions · 245 findings · 9 reviews · Gut

No studies found 76 · 31%GRADE not reported 3 · 1.2%Very low 106 · 43.3%Low 47 · 19.2%Moderate 12 · 4.9%High 1 · 0.4%

Summary of findings table ‐ Stem Cell vs placebo or control

CDAI <150 at 24 weeks · Induction of Remission in Medically Refractory Crohn's Disease

It is very uncertain whether summary of findings table ‐ Stem Cell changes CDAI <150 at 24 weeks compared with placebo or Control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Fistula Closure short‐term · Induction of Remission in Medically Refractory Crohn's Disease

Summary of findings table ‐ Stem Cell may leads to higher fistula Closure short‐term compared with placebo or Control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Fistula closure in long‐term · Induction of Remission in Medically Refractory Crohn's Disease

Summary of findings table ‐ Stem Cell may leads to higher fistula closure in long‐term compared with placebo or Control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Total adverse events · Induction of Remission in Medically Refractory Crohn's Disease

It is very uncertain whether summary of findings table ‐ Stem Cell changes total Adverse Events compared with placebo or Control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Stem Cell vs placebo or control

Withdrawals due to adverse events · Induction of Remission in Medically Refractory Crohn's Disease

It is very uncertain whether summary of findings table ‐ Stem Cell changes withdrawal due to adverse events compared with placebo or Control (very low certainty).

1 finding from 1 review

5‐ASA vs placebo

Relapse, drop‐outs classed as relapse, grouped by length of · patients with maintenance of medically‐induced remission in Crohn's disease

5‐ASA showed no clear difference in relapse, drop‐outs classed as relapse, grouped by length of compared with placebo (moderate certainty).

3 findings from 1 review

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review

Laparoscopic fundoplication vs medical management

(5 years or more) · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes (5 years or more) compared with medical management (very low certainty).

1 finding from 1 review