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What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 7 reviews · Airways · Headline outcomes only

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No studies found 1 · 6.3%GRADE not reported 0 · 0%Very low 1 · 6.3%Low 6 · 37.5%Moderate 8 · 50%High 0 · 0%

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Exacerbations: number of people experiencing moderate or severe exacerbations · treatment for asthma in adults and children with asthma and GORD

Medical or surgical intervention, or both, for gastro‐oesophageal… showed no clear difference in number of participants with moderate/severe acute exacerbations… compared with nil intervention, delayed intervention control, or placebo (low certainty).

1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Lung function: FEV1 mL (change from baseline) · treatment for asthma in adults and children with asthma and GORD
1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Use of "rescue" medications and emergency action plans: B2 use puffs per day Duration of treatment: range 14 weeks to 24 weeks · treatment for asthma in adults and children with asthma and GORD
1 finding from 1 review

Medical or surgical intervention, or both, for gastro‐oesophageal reflux disease vs nil intervention, delayed intervention control, or placebo

Healthcare utilisation ‐ not measured · treatment for asthma in adults and children with asthma and GORD

The review found no eligible studies for this question.

1 finding from 1 review

Effects of school‐based asthma interventions vs usual care

Unplanned visit to hospital or GP due to asthma symptoms (unplanned medical visits) · children with asthma

Effects of school‐based asthma interventions probably leads to lower unplanned visit to hospital or GP due to asthma symptoms (unplanned… compared with usual care (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Non‐invasive ventilation vs usual care

All‐cause mortality · Patients admitted to hospital with acute hypercapnic respiratory failure due to an exacerbation of chronic obstructive pulmonary disease…

Non‐invasive ventilation probably leads to lower mortality compared with usual medical care (moderate certainty).

1 finding from 1 review

Non‐invasive ventilation vs usual care

Need for intubation · Patients admitted to hospital with acute hypercapnic respiratory failure due to an exacerbation of chronic obstructive pulmonary disease…

Non‐invasive ventilation probably leads to lower need for endotracheal intubation compared with usual medical care (moderate certainty).

1 finding from 1 review