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Evidence found and GRADE certainty

49 questions · 50 findings · 4 reviews

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No studies found 6 · 12%GRADE not reported 1 · 2%Very low 15 · 30%Low 20 · 40%Moderate 5 · 10%High 3 · 6%

Magnesium sulfate vs ipratropium

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether magnesium sulfate changes proportion of people with hospital admissions (from the emergency… compared with standard care (ipratropium bromide) (very low certainty).

1 finding from 1 review

Magnesium sulfate vs ipratropium

Endotracheal intubation To discharge · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether magnesium sulfate changes proportion of people requiring endotracheal intubation compared with standard care (ipratropium bromide) (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring ventilatory support (NIV or assisted ventilation) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ventilatory support (NIV or assisted… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (very low certainty).

1 finding from 1 review

Nebulised magnesium sulfate + standard care vs placebo + standard care

Incidence of admissions to the ICU · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether nebulised magnesium sulfate + standard care changes proportion of people requiring ICU admission compared with placebo + standard care (very low certainty).

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

Intravenous magnesium sulfate + standard care may leads to lower proportion of people with hospital admissions (from the emergency… compared with placebo + standard care (low certainty).

1 finding from 1 review

Intravenous magnesium sulfate + standard care vs placebo + standard care

Proportion of people requiring non‐invasive ventilation · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether intravenous magnesium sulfate + standard care changes proportion of people requiring non‐invasive ventilation compared with placebo + standard care (very low certainty).

1 finding from 1 review