Findings

What do systematic reviews say?

23 questions · 23 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 26.1%Low 17 · 73.9%Moderate 0 · 0%High 0 · 0%

MOFS‐LE vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.26 [0.68, 2.31]
5 studies · 369 participants
Low

MOFS‐LE vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 234 participants
Low

MOFS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 347 participants
Very low

MOFS‐LE vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.49]
4 studies · 314 participants
Low

MOFS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.94 [0.62, 1.42]
5 studies · 346 participants
Low

MOFS‐LE vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.43 [0.06, 2.85]
3 studies · 256 participants
Low

MOFS‐LE vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

MOFS‐LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.78 [0.29, 2.13]
4 studies · 314 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 347 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.65]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Death at hospital discharge · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.15, 6.64]
1 study · 60 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.16 [0.4, 3.35]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.69 [0.56, 5.11]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.91]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.24 [0.03, 1.87]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.21 [0.5, 2.92]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.9]
9 studies · 855 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.75, 1.34]
6 studies · 581 participants
Low