Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

145 questions · 157 findings · 13 reviews · Pain, Palliative and Supportive Care

No studies found 46 · 29.3%GRADE not reported 11 · 7%Very low 43 · 27.4%Low 39 · 24.8%Moderate 14 · 8.9%High 4 · 2.5%

Laminectomy plus radiotherapy vs radiotherapy

Ambulation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes ambulation At four months compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Survival At four months · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes survival At four months compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Reduced use of analgesics · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes reduction in analgesic use compared with radiotherapy (very low certainty).

1 finding from 1 review

Laminectomy plus radiotherapy vs radiotherapy

Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes urinary continence One month after treatment compared with radiotherapy (very low certainty).

1 finding from 1 review

Single‐fraction radiotherapy (8 Gy) vs short‐course radiotherapy (16 Gy

Ambulation · adults with metastatic extradural spinal cord compression (poor prognosis with visceral metastasis, and no spinal instability or bony…

Single‐fraction radiotherapy (8 Gy) showed no clear difference in ambulation One month after radiation compared with short‐course radiotherapy (16 Gy (moderate certainty).

1 finding from 1 review