Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

132 questions · 135 findings · 30 reviews · Neonatal

No studies found 16 · 11.9%GRADE not reported 14 · 10.4%Very low 30 · 22.2%Low 45 · 33.3%Moderate 27 · 20%High 3 · 2.2%

Intermittent phototherapy vs continuous phototherapy

Bilirubin‐induced brain dysfunction (defined as either the pathological finding of deep‐yellow staining of neurons and neuronal necrosis of the basal ganglia and brainstem nuclei or acute or chronic neurological deficit including athetoid cerebral... · neonatal jaundice
1 finding from 1 review

Turning position vs supine under phototherapy

Rate of decline of serum bilirubin (micromol/L/hr) · term and preterm neonates with hyperbilirubinaemia

Turning position showed no clear difference in rate of fall of serum total bilirubin at 24 hours of starting… compared with supine under phototherapy (low certainty).

1 finding from 1 review

Phototherapy with LED vs non‐LED light source

Rate of decline of serum bilirubin (micromol/L/hr) · newborn infants with unconjugated hyperbilirubinaemia

Phototherapy with LED showed no clear difference in rate of decline of serum total bilirubin mg/dL/hour compared with non‐LED light source (high certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of ET (≥ 1); placebo‐controlled studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of ET (≥ 1); placebo‐controlled studies compared with phototherapy alone (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin plus phototherapy vs phototherapy alone

Use of top‐up transfusion in 1st week of life; all studies · neonates with alloimmune hemolytic disease

Intravenous immunoglobulin plus phototherapy showed no clear difference in use of top‐up transfusion in 1st week of life; all studies compared with phototherapy alone (low certainty).

1 finding from 1 review